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  ENGLISH TITLE      Descriptive histopathologic animal study of ethambutol toxic optic neuropathy in the rat model.
  PERSONAL AUTHOR(S)      Bernardo EM III
  PERSONAL AUTHOR(S)      Tamesis JM Jr.
  PERSONAL AUTHOR(S)      Cloma LD
  PERSONAL AUTHOR(S)      Valera EG
  PERSONAL AUTHOR(S)      Sy CA
  SOURCE DOCUMENT      UERMMMC J Health Sci 2007 Mar 10(1):46-48
  ENCODER      Lorna
  PHYSICAL CLASSIFICATION      PR
  TYPE OF MATERIAL/DOCUMENT      AR
  LANGUAGE OF TEXT      En
  SUBJECT HEADINGS (MESH)      ETHAMBUTOL
  SUBJECT HEADINGS (MESH)      OPTIC NERVE DISEASES
  KEYWORDS (NON-MESH)     
  ABSTRACT      This study aims to describe and characterize histopathologic changes in the retinal ganglion cell layer and optic nerve of adult albino rates secondary to the administration of the so called safe doses of Ethambutol.
  ABSTRACT      A total of four treatment groups were used with the following dosing regimens: placebo, 15 mg/kg, 25 mg/kg and 50 mg/kg. After four weeks of Ethambutol treatment, the rats were sacrificed and the globe and proximal 4 mm of optic nerve was harvested. Histopathologic examination of the optic nerve-pupil section and cross sections of the proximal 2mm of optic nerve was done.
  ABSTRACT      All groups given variable doses of ethambutol did not show any observable decrease in the retinal ganglion cell density; neither did any treatment group exhibit any observable optic nerve changes. However, changes in the outer nuclear layer (ONL) were noted as either a decrease in cell density, an increase in cell density or a complete absence of the ONL.
  ABSTRACT      No observable change in the retinal ganglion cell layer nor the proximal 2mm of the optic nerve were observed among the treatment groups. Changes in the ONL was noted among those rats given ethambutol at doe as low as 15mg/kg/day. (Auth)
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