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  ENGLISH TITLE      Zinc supplementation among very low birth weight preterm infants in augmenting weight gain and prevention of nosocomial infections: a randomized, controlled trial.
  PERSONAL AUTHOR(S)      Gonzaga-Sahi LP
  PERSONAL AUTHOR(S)      Mantaring JB III
  SOURCE DOCUMENT      Philipp J Pediatr 2007 Oct-Dec 56(4):216-221
  ENCODER      Lorna
  PHYSICAL CLASSIFICATION      PR
  TYPE OF MATERIAL/DOCUMENT      AR
  LANGUAGE OF TEXT      En
  SUBJECT HEADINGS (MESH)      BIRTH WEIGHT
  SUBJECT HEADINGS (MESH)      INFANT, LOW BIRTH WEIGHT
  SUBJECT HEADINGS (MESH)      ZINC
  SUBJECT HEADINGS (MESH)      SEPSIS
  SUBJECT HEADINGS (MESH)      PREMATURE BIRTH
  SUBJECT HEADINGS (MESH)      CROSS INFECTION
  KEYWORDS (NON-MESH)     
  ABSTRACT      The objective is to determine the efficacy of zinc supplementation in augmenting weight gain and in the prevention of nosocomial infection among very low birth weight preterm infants. This is a randomized, double-blinded, controlled trial. This study was conducted at a tertiary government hospital. All infants born ≤34 weeks gestational age with a birth weight ≤1500g and receiving at least 50 mL/kg/day of milk were considered eligible for the study. A total of 98 infants were recruited and all were accounted for at the end of the study. Subjects were randomized to receive or not to receive 5 mg of elemental zinc daily from the day they were enrolled until they reached the weight of 1800g for until they were discharged, whichever comes first. Fifty subjects were randomized to the zinc supplementation group and 49 to the control group. The groups were comparable in terms of gestational age, birth and entry anthropometrics; and sex distribution. There was no significant difference in the increments per day of weight and increments per week of length, head, chest, abdominal and mid upper arm circumstances; and skin fold thickness between the two groups. There was no significant difference in the occurrence of sepsis, death and feeding intolerance between the two groups. The incidence of nosocomial sepsis in the zinc group was 6% (3), vs. 8.3% (4) in the control group, with a decrease in the risk for nosocomial infection by 2.3% (p=0.96). There was no significant difference in occurrence of death, (zinc group = 4% (2) vs control group = 2% (1), (p value = 0.97) between the two groups. There was no significant difference in the growth parameters such as weight, length, head, chest, abdominal and mid-upper arm circumferences; and skin fold thickness between the two groups. No difference in the incidence of nosocomial infection and death was seen between the two treatment groups. Future studies on zinc supplementation with longer duration of intervention is recommended. (Auth)
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